Incomplete cytokinesis and re-fusion of small mononucleated Hodgkin cells lead to giant multinucleated Reed–Sternberg cells

Multinucleated Reed–Sternberg (RS) cells are pathognomonic for classical Hodgkin lymphoma (HL), and their presence is essential for diagnosis. How these giant tumor cells develop is controversial, however. It has been postulated that RS cells arise from mononucleated Hodgkin cells via endomitosis. C...

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Hauptverfasser: Rengstl, Benjamin, Newrzela, Sebastian, Heinrich, Tim, Weiser, Christian, Thalheimer, Frederic B., Schmid, Frederike, Warner, Kathrin, Hartmann, Sylvia, Schroeder, Timm, Küppers, Ralf, Rieger, Michael A., Hansmann, Martin-Leo
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870723/
https://ncbi.nlm.nih.gov/pubmed/24302766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312509110
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