Incomplete cytokinesis and re-fusion of small mononucleated Hodgkin cells lead to giant multinucleated Reed–Sternberg cells

Multinucleated Reed–Sternberg (RS) cells are pathognomonic for classical Hodgkin lymphoma (HL), and their presence is essential for diagnosis. How these giant tumor cells develop is controversial, however. It has been postulated that RS cells arise from mononucleated Hodgkin cells via endomitosis. C...

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Detaylı Bibliyografya
Asıl Yazarlar: Rengstl, Benjamin, Newrzela, Sebastian, Heinrich, Tim, Weiser, Christian, Thalheimer, Frederic B., Schmid, Frederike, Warner, Kathrin, Hartmann, Sylvia, Schroeder, Timm, Küppers, Ralf, Rieger, Michael A., Hansmann, Martin-Leo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2013
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870723/
https://ncbi.nlm.nih.gov/pubmed/24302766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312509110
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