The Precise Structures and Stereochemistry of Trihydroxy-linoleates Esterified in Human and Porcine Epidermis and Their Significance in Skin Barrier Function: IMPLICATION OF AN EPOXIDE HYDROLASE IN THE TRANSFORMATIONS OF LINOLEATE

Creation of an intact skin water barrier, a prerequisite for life on dry land, requires the lipoxygenase-catalyzed oxidation of the essential fatty acid linoleate, which is esterified to the ω-hydroxyl of an epidermis-specific ceramide. Oxidation of the linoleate moiety by lipoxygenases is proposed...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Chiba, Takahito, Thomas, Christopher P., Calcutt, M. Wade, Boeglin, William E., O'Donnell, Valerie B., Brash, Alan R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2016
Teme:
Lipids
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938176/
https://ncbi.nlm.nih.gov/pubmed/27151221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.711267
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