Epoxide hydrolase 3 (Ephx3) gene disruption reduces ceramide linoleate epoxide hydrolysis and impairs skin barrier function

The mammalian epoxide hydrolase (EPHX)3 is known from in vitro experiments to efficiently hydrolyze the linoleate epoxides 9,10-epoxyoctadecamonoenoic acid (EpOME) and epoxyalcohol 9R,10R-trans-epoxy-11E-13R-hydroxy-octadecenoate to corresponding diols and triols, respectively. Herein we examined th...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Edin, Matthew L., Yamanashi, Haruto, Boeglin, William E., Graves, Joan P., DeGraff, Laura M., Lih, Fred B., Zeldin, Darryl C., Brash, Alan R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948417/
https://ncbi.nlm.nih.gov/pubmed/33334892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.016570
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