Epoxide hydrolase 1 (EPHX1) hydrolyzes epoxyeicosanoids and impairs cardiac recovery after ischemia

Stimuli such as inflammation or hypoxia induce cytochrome P450 epoxygenase-mediated production of arachidonic acid–derived epoxyeicosatrienoic acids (EETs). EETs have cardioprotective, vasodilatory, angiogenic, anti-inflammatory, and analgesic effects, which are diminished by EET hydrolysis yielding...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Edin, Matthew L., Hamedani, Behin Gholipour, Gruzdev, Artiom, Graves, Joan P., Lih, Fred B., Arbes, Samuel J., Singh, Rohanit, Orjuela Leon, Anette C., Bradbury, J. Alyce, DeGraff, Laura M., Hoopes, Samantha L., Arand, Michael, Zeldin, Darryl C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5836130/
https://ncbi.nlm.nih.gov/pubmed/29298899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000298
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