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The role of islet antigen presenting cells and the presentation of insulin in the initiation of autoimmune diabetes in the NOD mouse

We have been examining antigen presentation and the antigen presenting cells (APC) in the islets of Langerhans of the non-obese diabetic (NOD) mouse. The purpose is to identify the earliest events that initiate autoimmunity in this confined tissue. Islets normally have a population of macrophages th...

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Detalhes bibliográficos
Publicado no:Immunol Rev
Main Authors: Unanue, Emil R., Ferris, Stephen T., Carrero, Javier A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938008/
https://ncbi.nlm.nih.gov/pubmed/27319351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imr.12430
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