Multiplex enhancer-reporter assays uncover unsophisticated TP53 enhancer logic

Transcription factors regulate their target genes by binding to regulatory regions in the genome. Although the binding preferences of TP53 are known, it remains unclear what distinguishes functional enhancers from nonfunctional binding. In addition, the genome is scattered with recognition sequences...

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Detalles Bibliográficos
Publicado en:Genome Res
Autores principales: Verfaillie, Annelien, Svetlichnyy, Dmitry, Imrichova, Hana, Davie, Kristofer, Fiers, Mark, Kalender Atak, Zeynep, Hulselmans, Gert, Christiaens, Valerie, Aerts, Stein
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937571/
https://ncbi.nlm.nih.gov/pubmed/27197205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.204149.116
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