iRegulon: From a Gene List to a Gene Regulatory Network Using Large Motif and Track Collections

Identifying master regulators of biological processes and mapping their downstream gene networks are key challenges in systems biology. We developed a computational method, called iRegulon, to reverse-engineer the transcriptional regulatory network underlying a co-expressed gene set using cis-regula...

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Main Authors: Janky, Rekin's, Verfaillie, Annelien, Imrichová, Hana, Van de Sande, Bram, Standaert, Laura, Christiaens, Valerie, Hulselmans, Gert, Herten, Koen, Naval Sanchez, Marina, Potier, Delphine, Svetlichnyy, Dmitry, Kalender Atak, Zeynep, Fiers, Mark, Marine, Jean-Christophe, Aerts, Stein
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109854/
https://ncbi.nlm.nih.gov/pubmed/25058159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003731
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