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Multiplex enhancer-reporter assays uncover unsophisticated TP53 enhancer logic

Transcription factors regulate their target genes by binding to regulatory regions in the genome. Although the binding preferences of TP53 are known, it remains unclear what distinguishes functional enhancers from nonfunctional binding. In addition, the genome is scattered with recognition sequences...

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Bibliografski detalji
Izdano u:Genome Res
Glavni autori: Verfaillie, Annelien, Svetlichnyy, Dmitry, Imrichova, Hana, Davie, Kristofer, Fiers, Mark, Kalender Atak, Zeynep, Hulselmans, Gert, Christiaens, Valerie, Aerts, Stein
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937571/
https://ncbi.nlm.nih.gov/pubmed/27197205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.204149.116
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