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Multiplex enhancer-reporter assays uncover unsophisticated TP53 enhancer logic

Transcription factors regulate their target genes by binding to regulatory regions in the genome. Although the binding preferences of TP53 are known, it remains unclear what distinguishes functional enhancers from nonfunctional binding. In addition, the genome is scattered with recognition sequences...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Genome Res
मुख्य लेखकों: Verfaillie, Annelien, Svetlichnyy, Dmitry, Imrichova, Hana, Davie, Kristofer, Fiers, Mark, Kalender Atak, Zeynep, Hulselmans, Gert, Christiaens, Valerie, Aerts, Stein
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Cold Spring Harbor Laboratory Press 2016
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937571/
https://ncbi.nlm.nih.gov/pubmed/27197205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.204149.116
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