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The effect of leaving groups on binding and reactivity in enzyme-free copying of DNA and RNA

The template-directed incorporation of nucleotides at the terminus of a growing primer is the basis of the transmission of genetic information. Nature uses polymerases-catalyzed reactions, but enzyme-free versions exist that employ nucleotides with organic leaving groups. The leaving group affects y...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Kervio, Eric, Sosson, Marilyne, Richert, Clemens
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937335/
https://ncbi.nlm.nih.gov/pubmed/27235418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw476
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