Cascade of Reduced Speed and Accuracy After Errors in Enzyme-Free Copying of Nucleic Acid Sequences

Non-enzymatic, template-directed synthesis of nucleic acids is a paradigm for self-replicating systems. The evolutionary dynamics of such systems depend on several factors, including the mutation rates, relative replication rates, and sequence characteristics of mutant sequences. We measured the kin...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Leu, Kevin, Kervio, Eric, Obermayer, Benedikt, Turk-MacLeod, Rebecca M., Yuan, Caterina, Luevano, Jesus-Mario, Chen, Eric, Gerland, Ulrich, Richert, Clemens, Chen, Irene A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557965/
https://ncbi.nlm.nih.gov/pubmed/23259600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3095558
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