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Modulating the Cascade architecture of a minimal Type I-F CRISPR-Cas system

Shewanella putrefaciens CN-32 contains a single Type I-Fv CRISPR-Cas system which confers adaptive immunity against bacteriophage infection. Three Cas proteins (Cas6f, Cas7fv, Cas5fv) and mature CRISPR RNAs were shown to be required for the assembly of an interference complex termed Cascade. The Cas...

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Publicat a:Nucleic Acids Res
Autors principals: Gleditzsch, Daniel, Müller-Esparza, Hanna, Pausch, Patrick, Sharma, Kundan, Dwarakanath, Srivatsa, Urlaub, Henning, Bange, Gert, Randau, Lennart
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937334/
https://ncbi.nlm.nih.gov/pubmed/27216815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw469
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