Modulating the Cascade architecture of a minimal Type I-F CRISPR-Cas system

Shewanella putrefaciens CN-32 contains a single Type I-Fv CRISPR-Cas system which confers adaptive immunity against bacteriophage infection. Three Cas proteins (Cas6f, Cas7fv, Cas5fv) and mature CRISPR RNAs were shown to be required for the assembly of an interference complex termed Cascade. The Cas...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Gleditzsch, Daniel, Müller-Esparza, Hanna, Pausch, Patrick, Sharma, Kundan, Dwarakanath, Srivatsa, Urlaub, Henning, Bange, Gert, Randau, Lennart
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937334/
https://ncbi.nlm.nih.gov/pubmed/27216815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw469
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