Lower Viral Loads and Slower CD4(+) T-Cell Count Decline in MRKAd5 HIV-1 Vaccinees Expressing Disease-Susceptible HLA-B*58:02

Background. HLA strongly influences human immunodeficiency virus type 1 (HIV-1) disease progression. A major contributory mechanism is via the particular HLA-presented HIV-1 epitopes that are recognized by CD8(+) T-cells. Different populations vary considerably in the HLA alleles expressed. We inves...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Leitman, Ellen M., Hurst, Jacob, Mori, Masahiko, Kublin, James, Ndung'u, Thumbi, Walker, Bruce D., Carlson, Jonathan, Gray, Glenda E., Matthews, Philippa C., Frahm, Nicole, Goulder, Philip J.R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936641/
https://ncbi.nlm.nih.gov/pubmed/26951820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiw093
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