The Hypervariable HIV-1 Capsid Protein Residues Comprise HLA-Driven CD8(+) T-Cell Escape Mutations and Covarying HLA-Independent Polymorphisms

One proposed HIV vaccine strategy is to induce Gag-specific CD8(+) T-cell responses that can corner the virus, through fitness cost of viral escape and unavailability of compensatory mutations. We show here that the most variable capsid residues principally comprise escape mutants driven by protecti...

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Detalhes bibliográficos
Main Authors: Crawford, Hayley, Matthews, Philippa C., Schaefer, Malinda, Carlson, Jonathan M., Leslie, Alasdair, Kilembe, William, Allen, Susan, Ndung'u, Thumbi, Heckerman, David, Hunter, Eric, Goulder, Philip J. R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Cellular Response to Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020512/
https://ncbi.nlm.nih.gov/pubmed/21106744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01879-10
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