Identification of Respiratory Syncytial Virus Nonstructural Protein 2 Residues Essential for Exploitation of the Host Ubiquitin System and Inhibition of Innate Immune Responses

Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection in young children worldwide. The RSV nonstructural protein 2 (NS2) is a multifunctional protein that primarily acts to antagonize the innate immune system by targeting STAT2 for proteasomal degradation. We inve...

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Bibliographic Details
Published in:J Virol
Main Authors: Whelan, Jillian N., Tran, Kim C., van Rossum, Damian B., Teng, Michael N.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Cellular Response to Infection
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936147/
https://ncbi.nlm.nih.gov/pubmed/27147743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00423-16
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