A novel TCR-like CAR with specificity for PR1/HLA-A2 effectively targets myeloid leukemia in vitro when expressed in human adult peripheral blood and cord blood T cells

BACKGROUND AIMS: The PR1 peptide, derived from the leukemia-associated antigens proteinase 3 and neutrophil elastase, is overexpressed on HLA-A2 in acute myeloid leukemia (AML). We developed a T cell receptor (TCR)-like monoclonal antibody (8F4) that binds the PR1/HLA-A2 complex on the surface of AM...

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Detalhes bibliográficos
Publicado no:Cytotherapy
Main Authors: Ma, Qing, Garber, Haven R., Lu, Sijie, He, Hong, Tallis, Eran, Ding, Xiaoling, Sergeeva, Anna, Wood, Michael S, Dotti, Gianpietro, Salvado, Barbara, Ruisaard, Kathryn, Clise-Dwyer, Karen, John, Lisa St, Rezvani, Katayoun, Alatrash, Gheath, Shpall, Elizabeth J., Molldrem, Jeffrey J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935572/
https://ncbi.nlm.nih.gov/pubmed/27265873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcyt.2016.05.001
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