PR1-Specific T Cells Are Associated with Unmaintained Cytogenetic Remission of Chronic Myelogenous Leukemia After Interferon Withdrawal

BACKGROUND: Interferon-α (IFN) induces complete cytogenetic remission (CCR) in 20–25% CML patients and in a small minority of patients; CCR persists after IFN is stopped. IFN induces CCR in part by increasing cytotoxic T lymphocytes (CTL) specific for PR1, the HLA-A2-restricted 9-mer peptide from pr...

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Bibliografske podrobnosti
Main Authors: Kanodia, Shreya, Wieder, Eric, Lu, Sijie, Talpaz, Moshe, Alatrash, Gheath, Clise-Dwyer, Karen, Molldrem, Jeffrey J.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909896/
https://ncbi.nlm.nih.gov/pubmed/20668669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011770
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