PR1-specific cytotoxic T lymphocytes are relatively frequent in umbilical cord blood and can be effectively expanded to target myeloid leukemia

BACKGROUND AIMS: PR1 is an HLA-A2 restricted leukemia-associated antigen derived from neutrophil elastase and proteinase 3, both of which are normally stored in the azurophil granules of myeloid cells but overexpressed in myeloid leukemic cells. PR1-specific cytotoxic lymphocytes (PR1-CTL) have acti...

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Udgivet i:Cytotherapy
Main Authors: St. John, Lisa S, Wan, Liping, He, Hong, Garber, Haven R., Clise-Dwyer, Karen, Alatrash, Gheath, Rezvani, Katayoun, Shpall, Elizabeth J., Bollard, Catherine M., Ma, Qing, Molldrem, Jeffrey J.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4934389/
https://ncbi.nlm.nih.gov/pubmed/27378343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcyt.2016.05.007
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