Membrane-Associated Proteinase 3 on Granulocytes and Acute Myeloid Leukemia Inhibits T Cell Proliferation

Proteinase 3 (P3), a serine protease expressed by myeloid cells, localized within azurophil granules, and also expressed on the cellular membrane of polymorphonuclear neutrophils (PMN), is the target of autoimmunity in granulomatosis with polyangiitis. PR1, an HLA-A2 restricted nonameric peptide der...

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Vydáno v:J Immunol
Hlavní autoři: Yang, Tian-Hui, St. John, Lisa S., Garber, Haven R., Kerros, Celine, Ruisaard, Kathryn E., Clise-Dwyer, Karen, Alatrash, Gheath, Ma, Qing, Molldrem, Jeffrey J.
Médium: Artigo
Jazyk:Inglês
Vydáno: AAI 2018
Témata:
Immune Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099529/
https://ncbi.nlm.nih.gov/pubmed/30021768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800324
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