The Effect of Dolutegravir on the Pharmacokinetics of Metformin in Healthy Subjects

BACKGROUND: Dolutegravir is an integrase strand transfer inhibitor (INSTI) licensed for use in HIV-1 infection and is an inhibitor of organic cation transporter 2 (OCT2). This study assessed the effect of dolutegravir on the pharmacokinetics of metformin, an OCT2 substrate. DESIGN: This was an open-...

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Detalhes bibliográficos
Publicado no:J Acquir Immune Defic Syndr
Main Authors: Song, Ivy H., Zong, Jian, Borland, Julie, Jerva, Fred, Wynne, Brian, Zamek-Gliszczynski, Maciej J., Humphreys, Joan E., Bowers, Gary D., Choukour, Mike
Formato: Artigo
Idioma:Inglês
Publicado em: JAIDS Journal of Acquired Immune Deficiency Syndromes 2016
Assuntos:
Clinical Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935531/
https://ncbi.nlm.nih.gov/pubmed/26974526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0000000000000983
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