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Effect of carbamazepine on dolutegravir pharmacokinetics and dosing recommendation

PURPOSE: Dolutegravir (DTG) is primarily metabolized by UGT1A1 with CYP3A as a minor route. Carbamazepine (CBZ) is a potent inducer of these enzymes; thus, the effect of oral extended-release CBZ on DTG pharmacokinetics (PK) was evaluated to provide dose recommendation when co-administered. METHODS:...

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Bibliografische gegevens
Gepubliceerd in:Eur J Clin Pharmacol
Hoofdauteurs: Song, Ivy, Weller, Steve, Patel, Juhin, Borland, Julie, Wynne, Brian, Choukour, Mike, Jerva, Fred, Piscitelli, Stephen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer Berlin Heidelberg 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865535/
https://ncbi.nlm.nih.gov/pubmed/26898568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-016-2020-6
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