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Effect of carbamazepine on dolutegravir pharmacokinetics and dosing recommendation
PURPOSE: Dolutegravir (DTG) is primarily metabolized by UGT1A1 with CYP3A as a minor route. Carbamazepine (CBZ) is a potent inducer of these enzymes; thus, the effect of oral extended-release CBZ on DTG pharmacokinetics (PK) was evaluated to provide dose recommendation when co-administered. METHODS:...
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| Gepubliceerd in: | Eur J Clin Pharmacol |
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| Hoofdauteurs: | , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Springer Berlin Heidelberg
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4865535/ https://ncbi.nlm.nih.gov/pubmed/26898568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-016-2020-6 |
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