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Comparative evaluation of N-acetylcysteine and N-acetylcysteineamide in acetaminophen-induced hepatotoxicity in human hepatoma HepaRG cells

Acetaminophen (N-acetyl-p-aminophenol, APAP) is one of the most widely used over-the-counter antipyretic analgesic medications. Despite being safe at therapeutic doses, an accidental or intentional overdose can result in severe hepatotoxicity; a leading cause of drug-induced liver failure in the U.S...

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Podrobná bibliografie
Vydáno v:Exp Biol Med (Maywood)
Hlavní autoři: Tobwala, Shakila, Khayyat, Ahdab, Fan, Weili, Ercal, Nuran
Médium: Artigo
Jazyk:Inglês
Vydáno: SAGE Publications 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935326/
https://ncbi.nlm.nih.gov/pubmed/25245075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1535370214549520
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