Histone deacetylases positively regulate transcription through the elongation machinery

Transcription elongation regulates the expression of many genes, including oncogenes. Histone deacetylase (HDAC) inhibitors (HDACIs) block elongation, suggesting HDACs are involved in gene activation. To understand this, we analyzed nascent transcription and elongation factor binding genome-wide aft...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Greer, Celeste B., Tanaka, Yoshiaki, Kim, Yoon Jung, Xie, Peng, Zhang, Michael Q., Park, In-Hyun, Kim, Tae Hoon
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4934896/
https://ncbi.nlm.nih.gov/pubmed/26549458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.10.013
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