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Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin
Affinity maturation by random mutagenesis and selection is an established technique to make binding molecules more suitable for applications in biomedical research, diagnostics and therapy. Here we identified an unexpected novel mechanism of affinity increase upon in vitro evolution of a tubulin-spe...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4933879/ https://ncbi.nlm.nih.gov/pubmed/27380724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28922 |
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