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Structural insight into the inhibition of tubulin by vinca domain peptide ligands

The tubulin vinca domain is the target of widely different microtubule inhibitors that interfere with the binding of vinblastine. Although all these ligands inhibit the hydrolysis of GTP, they affect nucleotide exchange to variable extents. The structures of two vinca domain antimitotic peptides—pho...

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Main Authors: Cormier, Anthony, Marchand, Matthieu, Ravelli, Raimond B G, Knossow, Marcel, Gigant, Benoît
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581847/
https://ncbi.nlm.nih.gov/pubmed/18787557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.171
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