A designed ankyrin repeat protein selected to bind to tubulin caps the microtubule plus end

Microtubules are cytoskeleton filaments consisting of αβ-tubulin heterodimers. They switch between phases of growth and shrinkage. The underlying mechanism of this property, called dynamic instability, is not fully understood. Here, we identified a designed ankyrin repeat protein (DARPin) that inter...

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Bibliografiske detaljer
Main Authors: Pecqueur, Ludovic, Duellberg, Christian, Dreier, Birgit, Jiang, Qiyang, Wang, Chunguang, Plückthun, Andreas, Surrey, Thomas, Gigant, Benoît, Knossow, Marcel
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409770/
https://ncbi.nlm.nih.gov/pubmed/22778434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204129109
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