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Altered Co-Translational Processing Plays a Role in Huntington's Pathogenesis—A Hypothesis
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by the expansion of a CAG codon repeat region in the HTT gene's first exon that results in huntingtin protein aggregation and neuronal cell death. The development of therapeutic treatments for HD is hinder...
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| Publié dans: | Front Mol Neurosci |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Frontiers Media S.A.
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4933702/ https://ncbi.nlm.nih.gov/pubmed/27458341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2016.00054 |
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