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Altered Co-Translational Processing Plays a Role in Huntington's Pathogenesis—A Hypothesis

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by the expansion of a CAG codon repeat region in the HTT gene's first exon that results in huntingtin protein aggregation and neuronal cell death. The development of therapeutic treatments for HD is hinder...

詳細記述

保存先:
書誌詳細
出版年:Front Mol Neurosci
主要な著者: Nissley, Daniel A., O'Brien, Edward P.
フォーマット: Artigo
言語:Inglês
出版事項: Frontiers Media S.A. 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933702/
https://ncbi.nlm.nih.gov/pubmed/27458341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2016.00054
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