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Domain topology, stability, and translation speed determine mechanical force generation on the ribosome

The concomitant folding of a nascent protein domain with its synthesis can generate mechanical forces that act on the ribosome and alter translation speed. Such changes in speed can affect the structure and function of the newly synthesized protein as well as cellular phenotype. The domain propertie...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Leininger, Sarah E., Trovato, Fabio, Nissley, Daniel A., O’Brien, Edward P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2019
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6431206/
https://ncbi.nlm.nih.gov/pubmed/30824598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1813003116
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