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Neogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the Liver
Hemojuvelin (HJV) regulates iron homeostasis by direct interaction with bone morphogenetic protein (BMP) ligands to induce hepcidin expression through the BMP signaling pathway in the liver. Crystallography studies indicate that HJV can simultaneously bind to both BMP2 and the ubiquitously expressed...
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| Veröffentlicht in: | J Biol Chem |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4933279/ https://ncbi.nlm.nih.gov/pubmed/27072365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.721191 |
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