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Hemojuvelin-Neogenin Interaction Is Required for Bone Morphogenic Protein-4-induced Hepcidin Expression

Hemojuvelin (HJV) is a glycosylphosphatidylinositol-linked protein and binds both bone morphogenic proteins (BMPs) and neogenin. Cellular HJV acts as a BMP co-receptor to enhance the transcription of hepcidin, a key iron regulatory hormone secreted predominantly by liver hepatocytes. In this study w...

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Autori principali: Zhang, An-Sheng, Yang, Fan, Wang, Jiaohong, Tsukamoto, Hidekazu, Enns, Caroline A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755665/
https://ncbi.nlm.nih.gov/pubmed/19564337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.027318
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