Interaction of the Hereditary Hemochromatosis Protein, HFE, with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression

The mechanisms that allow the body to sense iron levels in order to maintain iron homeostasis are unknown. Patients with the most common form of hereditary iron overload have mutations in the hereditary hemochromatosis protein, HFE. They have lower levels of hepcidin, than unaffected individuals. He...

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Bibliografiske detaljer
Main Authors: Gao, Junwei, Chen, Juxing, Kramer, Maxwell, Tsukamoto, Hidekazu, Zhang, An-Sheng, Enns, Caroline A.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673483/
https://ncbi.nlm.nih.gov/pubmed/19254567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.01.010
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