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The Role of Hepatocyte Hemojuvelin in the Regulation of Bone Morphogenic Protein-6 and Hepcidin Expression in Vivo

Both hemojuvelin (HJV) and bone morphogenic protein-6 (BMP6) are essential for hepcidin expression. Hepcidin is the key peptide hormone in iron homeostasis, and is secreted predominantly by hepatocytes. HJV expression is detected in hepatocytes, as well as in skeletal and heart muscle. HJV binds BMP...

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Autors principals: Zhang, An-Sheng, Gao, Junwei, Koeberl, Dwight D., Enns, Caroline A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878008/
https://ncbi.nlm.nih.gov/pubmed/20363739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.109488
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