Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice

Hereditary hemochromatosis is caused by mutations in the hereditary hemochromatosis protein (HFE), transferrin-receptor 2 (TfR2), hemojuvelin, hepcidin, or ferroportin genes. Hepcidin is a key iron regulator, which is secreted by the liver, and decreases serum iron levels by causing the down-regulat...

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Hlavní autoři: Gao, Junwei, Chen, Juxing, De Domenico, Ivana, Koeller, David M., Harding, Cary O., Fleming, Robert E., Koeberl, Dwight D., Enns, Caroline A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2010
Témata:
Red Cells, Iron, and Erythropoiesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858491/
https://ncbi.nlm.nih.gov/pubmed/20177050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-09-245209
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