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Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice
Hereditary hemochromatosis is caused by mutations in the hereditary hemochromatosis protein (HFE), transferrin-receptor 2 (TfR2), hemojuvelin, hepcidin, or ferroportin genes. Hepcidin is a key iron regulator, which is secreted by the liver, and decreases serum iron levels by causing the down-regulat...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Hematology
2010
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2858491/ https://ncbi.nlm.nih.gov/pubmed/20177050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-09-245209 |
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