Molecular Features of Phosphatase and Tensin Homolog (PTEN) Regulation by C-terminal Phosphorylation

PTEN is a tumor suppressor that functions to negatively regulate the PI3K/AKT pathway as the lipid phosphatase for phosphatidylinositol 3,4,5-triphosphate. Phosphorylation of a cluster of Ser/Thr residues (amino acids 380–385) on the C-terminal tail serves to alter the conformational state of PTEN f...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Chen, Zan, Dempsey, Daniel R., Thomas, Stefani N., Hayward, Dawn, Bolduc, David M., Cole, Philip A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2016
Teme:
Enzymology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933174/
https://ncbi.nlm.nih.gov/pubmed/27226612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.728980
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