Rearrangement of the Extracellular Domain/Extracellular Loop 1 Interface Is Critical for Thyrotropin Receptor Activation

The thyroid stimulating hormone receptor (TSHR) is a G protein-coupled receptor (GPCR) with a characteristic large extracellular domain (ECD). TSHR activation is initiated by binding of the hormone ligand TSH to the ECD. How the extracellular binding event triggers the conformational changes in the...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Schaarschmidt, Joerg, Nagel, Marcus B. M., Huth, Sandra, Jaeschke, Holger, Moretti, Rocco, Hintze, Vera, von Bergen, Martin, Kalkhof, Stefan, Meiler, Jens, Paschke, Ralf
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933169/
https://ncbi.nlm.nih.gov/pubmed/27129207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.709659
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