Rearrangement of the Extracellular Domain/Extracellular Loop 1 Interface Is Critical for Thyrotropin Receptor Activation

The thyroid stimulating hormone receptor (TSHR) is a G protein-coupled receptor (GPCR) with a characteristic large extracellular domain (ECD). TSHR activation is initiated by binding of the hormone ligand TSH to the ECD. How the extracellular binding event triggers the conformational changes in the...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Schaarschmidt, Joerg, Nagel, Marcus B. M., Huth, Sandra, Jaeschke, Holger, Moretti, Rocco, Hintze, Vera, von Bergen, Martin, Kalkhof, Stefan, Meiler, Jens, Paschke, Ralf
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2016
Pynciau:
Cell Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933169/
https://ncbi.nlm.nih.gov/pubmed/27129207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.709659
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg