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Principles and Determinants of G-Protein Coupling by the Rhodopsin-Like Thyrotropin Receptor
In this study we wanted to gain insights into selectivity mechanisms between G-protein-coupled receptors (GPCR) and different subtypes of G-proteins. The thyrotropin receptor (TSHR) binds G-proteins promiscuously and activates both Gs (cAMP) and Gq (IP). Our goal was to dissect selectivity patterns...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2841179/ https://ncbi.nlm.nih.gov/pubmed/20305779 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009745 |
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