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B-cell–independent sialylation of IgG
IgG carrying terminal α2,6-linked sialic acids added to conserved N-glycans within the Fc domain by the sialyltransferase ST6Gal1 accounts for the anti-inflammatory effects of large-dose i.v. Ig (IVIg) in autoimmunity. Here, B-cell–specific ablation of ST6Gal1 in mice revealed that IgG sialylation c...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4932940/ https://ncbi.nlm.nih.gov/pubmed/27303031 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523968113 |
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