B-cell–independent sialylation of IgG

IgG carrying terminal α2,6-linked sialic acids added to conserved N-glycans within the Fc domain by the sialyltransferase ST6Gal1 accounts for the anti-inflammatory effects of large-dose i.v. Ig (IVIg) in autoimmunity. Here, B-cell–specific ablation of ST6Gal1 in mice revealed that IgG sialylation c...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Jones, Mark B., Oswald, Douglas M., Joshi, Smita, Whiteheart, Sidney W., Orlando, Ron, Cobb, Brian A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2016
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932940/
https://ncbi.nlm.nih.gov/pubmed/27303031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523968113
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