Azacytidine mitigates experimental sclerodermic chronic graft-versus-host disease

BACKGROUND: Previous studies have demonstrated that regulatory T cells (Tregs) play a protective role in the pathogenesis of chronic graft-versus-host disease (cGVHD). Tregs constitutively express the gene of the transcription factor Foxp3 whose CNS2 region is heavily methylated in conventional CD4(...

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Dettagli Bibliografici
Pubblicato in:J Hematol Oncol
Autori principali: Fransolet, Gilles, Ehx, Grégory, Somja, Joan, Delens, Loïc, Hannon, Muriel, Muller, Joséphine, Dubois, Sophie, Drion, Pierre, Caers, Jo, Humblet-Baron, Stéphanie, Delvenne, Philippe, Beguin, Yves, Conteduca, Giuseppina, Baron, Frédéric
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932697/
https://ncbi.nlm.nih.gov/pubmed/27377819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-016-0281-2
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