The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers

The pharmacokinetics, pharmacodynamics, safety, and tolerability of BMS-932481, a γ-secretase modulator (GSM), were tested in healthy young and elderly volunteers after single and multiple doses. BMS-932481 was orally absorbed, showed dose proportionality after a single dose administration, and had...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Pharmacol Exp Ther
Κύριοι συγγραφείς: Soares, Holly D., Gasior, Maciej, Toyn, Jeremy H., Wang, Jun-Sheng, Hong, Quan, Berisha, Flora, Furlong, Michael T., Raybon, Joseph, Lentz, Kimberley A., Sweeney, Francis, Zheng, Naiyu, Akinsanya, Billy, Berman, Robert M., Thompson, Lorin A., Olson, Richard E., Morrison, John, Drexler, Dieter M., Macor, John E., Albright, Charlie F., Ahlijanian, Michael K., AbuTarif, Malaz
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: The American Society for Pharmacology and Experimental Therapeutics 2016
Θέματα:
Drug Discovery and Translational Medicine
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931877/
https://ncbi.nlm.nih.gov/pubmed/27189973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.232256
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