HSV‐1 ICP27 targets the TBK1‐activated STING signalsome to inhibit virus‐induced type I IFN expression

Herpes simplex virus (HSV) 1 stimulates type I IFN expression through the cGAS–STING–TBK1 signaling axis. Macrophages have recently been proposed to be an essential source of IFN during viral infection. However, it is not known how HSV‐1 inhibits IFN expression in this cell type. Here, we show that...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Christensen, Maria H, Jensen, Søren B, Miettinen, Juho J, Luecke, Stefanie, Prabakaran, Thaneas, Reinert, Line S, Mettenleiter, Thomas, Chen, Zhijian J, Knipe, David M, Sandri‐Goldin, Rozanne M, Enquist, Lynn W, Hartmann, Rune, Mogensen, Trine H, Rice, Stephen A, Nyman, Tuula A, Matikainen, Sampsa, Paludan, Søren R
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931188/
https://ncbi.nlm.nih.gov/pubmed/27234299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201593458
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