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Monosodium Urate Activates Src/Pyk2/PI3 Kinase and Cathepsin Dependent Unconventional Protein Secretion From Human Primary Macrophages

Monosodium urate (MSU) is an endogenous danger signal that is crystallized from uric acid released from injured cells. MSU is known to activate inflammatory response in macrophages but the molecular mechanisms involved have remained uncharacterized. Activated macrophages start to secrete proteins to...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Välimäki, Elina, Miettinen, Juho J., Lietzén, Niina, Matikainen, Sampsa, Nyman, Tuula A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Biochemistry and Molecular Biology 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591666/
https://ncbi.nlm.nih.gov/pubmed/23292187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M112.024661
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