HSV‐1 ICP27 targets the TBK1‐activated STING signalsome to inhibit virus‐induced type I IFN expression

Herpes simplex virus (HSV) 1 stimulates type I IFN expression through the cGAS–STING–TBK1 signaling axis. Macrophages have recently been proposed to be an essential source of IFN during viral infection. However, it is not known how HSV‐1 inhibits IFN expression in this cell type. Here, we show that...

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Bibliografiska uppgifter
I publikationen:EMBO J
Huvudupphovsmän: Christensen, Maria H, Jensen, Søren B, Miettinen, Juho J, Luecke, Stefanie, Prabakaran, Thaneas, Reinert, Line S, Mettenleiter, Thomas, Chen, Zhijian J, Knipe, David M, Sandri‐Goldin, Rozanne M, Enquist, Lynn W, Hartmann, Rune, Mogensen, Trine H, Rice, Stephen A, Nyman, Tuula A, Matikainen, Sampsa, Paludan, Søren R
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2016
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931188/
https://ncbi.nlm.nih.gov/pubmed/27234299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201593458
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