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Efficient Nuclear Export of Herpes Simplex Virus 1 Transcripts Requires both RNA Binding by ICP27 and ICP27 Interaction with TAP/NXF1

Herpes simplex virus 1 (HSV-1) regulatory protein ICP27 has been reported to bind viral RNA and to interact with the nuclear export adaptor Aly/REF and the major cellular mRNA nuclear export receptor TAP/NXF1. Using in situ hybridization and in vitro export assays, we show here that poly(A)(+) RNA w...

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Detalhes bibliográficos
Main Authors: Johnson, Lisa A., Sandri-Goldin, Rozanne M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2620904/
https://ncbi.nlm.nih.gov/pubmed/19019956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02010-08
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