The tumor-associated glycosyltransferase ST6Gal-I regulates stem cell transcription factors and confers a cancer stem cell phenotype

The glycosyltransferase ST6Gal-I which adds α2-6-linked sialic acids to substrate glycoproteins has been implicated in carcinogenesis, however, the nature of its pathogenic role remains poorly understood. Here we show that ST6Gal-I is upregulated in ovarian and pancreatic carcinomas, enriched in met...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Schultz, Matthew J., Holdbrooks, Andrew T., Chakraborty, Asmi, Grizzle, William E., Landen, Charles N., Buchsbaum, Donald J., Conner, Michael G., Arend, Rebecca C., Yoon, Karina J, Klug, Christopher A., Bullard, Daniel C., Kesterson, Robert A., Oliver, Patsy G., O’Connor, Amber K., Yoder, Bradley K., Bellis, Susan L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4930726/
https://ncbi.nlm.nih.gov/pubmed/27216178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2834
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