The tumor-associated glycosyltransferase ST6Gal-I regulates stem cell transcription factors and confers a cancer stem cell phenotype

The glycosyltransferase ST6Gal-I which adds α2-6-linked sialic acids to substrate glycoproteins has been implicated in carcinogenesis, however, the nature of its pathogenic role remains poorly understood. Here we show that ST6Gal-I is upregulated in ovarian and pancreatic carcinomas, enriched in met...

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Bibliographic Details
Published in:Cancer Res
Main Authors: Schultz, Matthew J., Holdbrooks, Andrew T., Chakraborty, Asmi, Grizzle, William E., Landen, Charles N., Buchsbaum, Donald J., Conner, Michael G., Arend, Rebecca C., Yoon, Karina J, Klug, Christopher A., Bullard, Daniel C., Kesterson, Robert A., Oliver, Patsy G., O’Connor, Amber K., Yoder, Bradley K., Bellis, Susan L.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4930726/
https://ncbi.nlm.nih.gov/pubmed/27216178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2834
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