Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice

AIMS/HYPOTHESIS: Lysosomal acid lipase (LAL) hydrolyses cholesteryl esters and triacylglycerols (TG) within lysosomes to mobilise NEFA and cholesterol. Since LAL-deficient (Lal(-/-)) mice suffer from progressive loss of adipose tissue and severe accumulation of lipids in hepatic lysosomes, we hypoth...

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Pubblicato in:Diabetologia
Autori principali: Radović, Branislav, Vujić, Nemanja, Leopold, Christina, Schlager, Stefanie, Goeritzer, Madeleine, Patankar, Jay V., Korbelius, Melanie, Kolb, Dagmar, Reindl, Julia, Wegscheider, Martin, Tomin, Tamara, Birner-Gruenberger, Ruth, Schittmayer, Matthias, Groschner, Lukas, Magnes, Christoph, Diwoky, Clemens, Frank, Saša, Steyrer, Ernst, Du, Hong, Graier, Wolfgang F., Madl, Tobias, Kratky, Dagmar
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4930475/
https://ncbi.nlm.nih.gov/pubmed/27153842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-016-3968-6
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