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The Pseudouridine Synthases Proceed through a Glycal Intermediate

[Image: see text] The pseudouridine synthases isomerize (U) in RNA to pseudouridine (Ψ), and the mechanism that they follow has long been a question of interest. The recent elucidation of a product of the mechanistic probe 5-fluorouridine that had been epimerized to the arabino isomer suggested that...

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Veerareddygari, Govardhan Reddy, Singh, Sanjay K., Mueller, Eugene G.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2016
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929527/
https://ncbi.nlm.nih.gov/pubmed/27292228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b04491
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