Catalysts of DNA Strand Cleavage at Apurinic/Apyrimidinic Sites

Apurinic/apyrimidinic (AP) sites are constantly formed in cellular DNA due to instability of the glycosidic bond, particularly at purines and various oxidized, alkylated, or otherwise damaged nucleobases. AP sites are also generated by DNA glycosylases that initiate DNA base excision repair. These l...

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Publicat a:Sci Rep
Autors principals: Minko, Irina G., Jacobs, Aaron C., de Leon, Arnie R., Gruppi, Francesca, Donley, Nathan, Harris, Thomas M., Rizzo, Carmelo J., McCullough, Amanda K., Lloyd, R. Stephen
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929455/
https://ncbi.nlm.nih.gov/pubmed/27363485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28894
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