Catalysts of DNA Strand Cleavage at Apurinic/Apyrimidinic Sites

Apurinic/apyrimidinic (AP) sites are constantly formed in cellular DNA due to instability of the glycosidic bond, particularly at purines and various oxidized, alkylated, or otherwise damaged nucleobases. AP sites are also generated by DNA glycosylases that initiate DNA base excision repair. These l...

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Publicado no:Sci Rep
Main Authors: Minko, Irina G., Jacobs, Aaron C., de Leon, Arnie R., Gruppi, Francesca, Donley, Nathan, Harris, Thomas M., Rizzo, Carmelo J., McCullough, Amanda K., Lloyd, R. Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929455/
https://ncbi.nlm.nih.gov/pubmed/27363485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28894
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