Catalysts of DNA Strand Cleavage at Apurinic/Apyrimidinic Sites

Apurinic/apyrimidinic (AP) sites are constantly formed in cellular DNA due to instability of the glycosidic bond, particularly at purines and various oxidized, alkylated, or otherwise damaged nucleobases. AP sites are also generated by DNA glycosylases that initiate DNA base excision repair. These l...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Minko, Irina G., Jacobs, Aaron C., de Leon, Arnie R., Gruppi, Francesca, Donley, Nathan, Harris, Thomas M., Rizzo, Carmelo J., McCullough, Amanda K., Lloyd, R. Stephen
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929455/
https://ncbi.nlm.nih.gov/pubmed/27363485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28894
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